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Новости/Аналитика

Scientists have discovered the structure of the main cannabinoid receptor

06.12.2016

The crystal structure of the CB1 receptor in the human body
Knowledge of the structure and the CB1 receptor structure will allow pharmacists around the world to develop effective therapeutics based on various compounds of cannabis designed to impact on certain parts of the receptor in order to achieve different therapeutic effects.
 
world public attention was attracted by the results of studies of US-Chinese expert group aimed at studying the structure of the CB1 cannabinoid receptor in the human body. During the X-ray analysis, scientists have concluded that it is crystalline. Because these receptors are responsible not only for the psychoactive effects of cannabis plants, but also for its therapeutic function, this discovery is a breakthrough in medical cannabis. Having an idea of ​​the structure of the receptor itself is now possible molecular modeling voxel CB1, which will track how cannabinoid compounds interact with them, and which thus effects occur.
 
Science known two types of cannabinoid receptors in the human body - CB1 and CB2. It is proved that the CB1 receptors are concentrated in the central nervous system and organs CB2 - immune. Both groups are, in turn, form the endocannabinoid system of the human body, which synthesizes its own so-called endogenous cannabinoids aimed at regulating the nervous system.
 
The immediate impact of cannabinoids on CB 1 receptors have a certain effect on the human body as a whole. This is seen by the example of tetrahydrocannabinol (THC), the main psychoactive component of cannabis, which is an active stimulus of the receptor. But not all so cannabinoids act on the CB1. For example, cannabidiol (CBD) does not have an intoxicating effect, characteristic of THC.
 
In any case, CB1 is an integral part of the human body and malfunctions lead to deterioration in general condition of the body and even, according to the scientists, can cause certain diseases. This phenomenon is due to the fact that inherently reacts CB1 not introduced at consumption fitokannabinoidy hemp, and cannabinoid compounds produced directly by the human body. Among these compounds of particular interest to medicine are anandamide and 2-AG, as they directly interact with CB1.
 
The existence of cannabinoid receptors has long been known, but their structure and mode of operation to this day have not been studied.
 
 
For a long time, hemp medicine was based on a method of trial and error. Now, knowledge of the structure and allow the structure CB1 receptor pharmacists around the world to develop effective therapeutics based on various compounds hemp directed to certain effects on the receptor part in order to achieve different therapeutic effects.
 
Without exaggeration, it can be argued that the results of the research team of scientists CB1 structures are tremendous breakthrough in medicine in general and in particular cannabis pharmacology.
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